Meetings
Home      학술발표회 - 초록 상세보기

  학술발표회 - 초록 상세보기

문의 : 초록( abstract@kcsnet.or.kr), 참가비( member@kcsnet.or.kr)

 

현재 가능한 작업은 아래와 같습니다.

  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능
대회명 대한화학회 제121회 학술발표회 및 총회
등록일 2018년 02월 07일 15시 17분 07초
접수번호 6616
발표코드 ANAL2.O-17 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간 금 10시 : 25분
발표형식 구두발표
발표분야 Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
저자 및 공동저자 SHARIPOV MIRKOMIL, Salah Mahmoud Tawfik Ahmed, YONG-ILL LEE*
Department of Chemistry, Changwon National University, Korea
제목 Phospholipase A2-responsive UCNPs-loaded Phosphate Micelles for Prostate Cancer Cells Imaging
내용 Rare-earth upconversion nanoparticles (UCNPs) have received the tremendous attention of researchers last decades due to their potential application as biological luminescent labels in bio-imaging application. However, it is still a challenge for researchers to obtain nontoxic, nanoscale, well dispersed and high selective nanoparticles. On the other hand, it has been reported that phospholipase A2(PLA-2) enzyme is abnormally overexpressed in several diseases such as pancreatitis or early stages of prostate cancer. Novel phosphate micelles from biocompatible compounds were synthesized and characterized for selective imaging of prostate cancer cells. Using fluorescence method, CMC value of the synthesized micelles was determined to be 0.638 mM. The activity of phospholipase A2 (PLA-2) enzyme toward the synthesized micelle was investigated and confirmed by LC-MS. This kind of surfactant can form UCNPs-loaded phosphate micelles formed from PLA-2 cleavable surfactant in order to deliver UCNPs directly to prostate tumor cells by reducing side effects on normal biological tissues. TEM results showed that micelles have size ranged from 80 nm to 150 nm; whereas size of UCNPs-loaded micelles ranges from 200nm to 350 nm. Cytotoxicity results confirmed the biocompatibility of micelles. Bio-imaging experiments conducted on KB and HeLa cell lines confirmed encapsulation of UCNPs in micelles thereby reducing the non-selective binding of UCNPs towards cells with low expression of PLA-2. Meanwhile, bio-imaging application on 22Rv1 prostate cancer cell line confirmed the selective release of UCNPs on the surface of the prostate cancer cells.reducing the non-selective binding of UCNPs towards cells with low expression of PLA-2. Meanwhile, bio-imaging application on 22Rv1 prostate cancer cell line confirmed the selective release of UCNPs on the surface of the prostate cancer cells.
- 등록된 그림이 있는경우 그림을 클릭하시면 원본 그림파일을 볼 수 있습니다.
- 최종본을 확인하지 않아 발생된 문제에 대해서는 책임지지 않습니다.
- 미리보기의 그림위치는 임시 위치입니다. 모든 그림파일은 Abstract 하단에 위치하게 됩니다.
목록