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제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Reactive oxygen species and thiol responsive micelles for efficient delivery of anti-cancer therapeutics

등록일
2018년 8월 14일 17시 44분 27초
접수번호
0206
발표코드
POLY.P-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Polymer Chemistry
저자 및
공동저자
Young In Choi, Hyun-Chul Kim*
Magnet-Controlled Materials Research Group, Daegu Gyeongbuk Institute of Science & Technology, Korea
Gemini amphiphile consisting of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(methionine) (PMT) with cystine disulfide spacers was synthesized and its micellar properties for thiol- or ROS (reactive oxygen species)-dependent intracellular drug delivery are described. The cleavage of cystine linkage in redox environment or the oxidation of methionine units in ROS environment caused the destabilization of micelles. Such redox- or ROS-triggered micellar destabilization led to enhanced release of encapsulated DOX (doxorubicin) to induce cytotoxicity against cancer cells. Therapeutic effects of the DOX-loaded micelles are demonstrated using KB cell line. This study shows that thiol and ROS dual responsive gemini micelles have potential use as a promising platforms for nano-drug delivery in various cancer therapies.

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