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09월 03일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능
대한화학회 제122회 학술발표회 및 총회
Alteration of plasma lipidome among five representative cancers by nUHPLC-ESI-MS/MS
2018년 8월 17일 09시 56분 31초
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10월 19일 (금요일) 11:00~12:30
Gwang Bin Lee
, JongCheol Lee
, Myeong Hee Moon
Department of Chemistry, Yonsei University, Korea
Cancer is one of the critical social problems as the incidence grows every year. Causes of cancer are known to be genetic factors, regimen, and environment conditions and so on. Because of the complexity of the cause, it is very important to understand the cause of cancer more clearly. Lipid is one of the substances that play key roles in the metabolism of human bodies and also known to be associated with various cellular processes such as survival, proliferation, and death. These cellular processes are associated with cancer genesis pathways, especially to transformation, progression, and metastasis, suggesting that lipids are mediators of carcinogenesis processes. In a recent research, lipidomic analysis as regard to cancer attracts more interests since each type of cancer has different carcinogenesis pathways and characteristics. In this study, plasma lipids from 5 different types of cancer patients (liver, gastric, lung, colorectal, and thyroid cancers) were investigated in order to figure out lipids that show significant differences among the groups and to find potential lipid biomarkers of each cancer. Lipids were extracted from blood plasma sample using the modified Folch method with MTBE/methanol, and analyzed by nUHPLC-ESI-MS/MS. Overall, 357 lipids from patient’s plasma with liver, stomach, lung, colorectal, thyroid cancer, and controls, were identified and 242 lipids were quantified by nUHPLC-ESI-MS/MS with statistical evaluations for the selection of candidate biomarkers.
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