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제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Effect of aging on lipid alteration in serum, kidney, and heart from mice by nUHPLC-ESI-MS/MS

2018년 8월 17일 09시 59분 18초
ANAL.P-331 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 19일 (금요일) 11:00~12:30
포스터 분석구두발표
Analytical Chemistry
저자 및
Jung Yong Eum, JongCheol Lee1, Myeong Hee Moon1,*
Yonsei University, Korea
1Department of Chemistry, Yonsei University, Korea
Lipids are the basic building blocks of cell membrane and are the sources of energy production and the crucial signaling molecules in controlling metabolism through activating or deactivating protein kinases, hormones or related metabolites. With lipid alteration in aging, however, these regulation processes gradually lose their control, and then eventually result in age-related diseases such as cardiovascular disease, neurodegenerative disease, and diabetes mellitus. Although a number of studies have been conducted to reveal the relationship between age-related diseases and lipids, only few studies have compared lipid changes with aging effect. In this study, lipid profiles in serum, kidney, and heart from C57BL/6 aging mice were examined to understand aging effect solely. Genetically well-controlled and raised 4 and 25-month-old mice which represent young and aged were analyzed by nanoflow ultrahigh pressure liquid chromatography-electrospray ionization-tandem mass spectrometry (nUHPLC-ESI-MS/MS). Above 350 lipid species were identified from each sample group and 163 from serum, 210 from kidney, and 202 from heart were quantified with internal standards of each class. From quantification, most significantly changed (> 1.5 fold and p < 0.01) lipid species were found to be down-regulated by aging, but PG and TG species were distinctively up-regulated in heart.