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  • 09월 03일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Profiling of lipoproteins from postmenopausal patients with osteoporosis by asymmetrical flow field-flow fractionation and nUPLC-ESI-MS/MS

2018년 8월 17일 10시 46분 59초
ANAL.P-335 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 19일 (금요일) 11:00~12:30
포스터 분석구두발표
Analytical Chemistry
저자 및
Kang geun Lee, Myeong Hee Moon*
Department of Chemistry, Yonsei University, Korea
Pathological mechanism of osteoporosis is unknown, but osteocytes affected by oxidized lipids inside the body have been known as a major factor. Bone mineral density (BMD) reaches at a highest level in mid 30s and decreases slowly over time, meaning that symptoms are hard to be detected and already serious when found out. Lipids play important roles in signal transmission, cell formation, and various cellular processes and they are expected to be biomarkers of a number of diseases. Therefore, it is interesting to study relationships between lipids consisting lipoproteins in plasma and osteoporosis for early diagnosis. There are several studies about lipids and osteoporosis in the medical field which BMD showed a positive correlation with low-density lipoprotein (LDL) and an inverse correlation with high-density lipoprotein (HDL). However, none of them conducted quantitative and qualitative analysis at the molecular level in detail. In this study, 39 plasma samples of woman were classified into three groups of patients in which women having osteoporosis with no clinical history (n=10), women having osteoporosis with history (n=7), age-matched control (n=22). Lipoproteins were first separated by sizes using asymmetrical flow field-flow fractionation and then lipids contained in HDL and LDL were analyzed by nanoflow ultrahigh-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (nUHPLC-ESI-MS/MS).