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  • 09월 03일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Biodegradable Double-Emulsion Nanoparticles Based on Polyfumarateurethane for Sustained Release of Bupivacaine

등록일
2018년 8월 20일 17시 19분 36초
접수번호
0475
발표코드
POLY.P-8 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Polymer Chemistry
저자 및
공동저자
Soo Yong Park, Ildoo Chung*
Department of Polymer Science and Engineering, Pusan National University, Korea

Biodegradable polyfumarateurethane (PFU) for delivery vehicle using di-(2-hydroxypropyl fumarate) (DHPF), PEG (polyethylene glycol) and HMDI (1,6-hexamethylene diisocyanate) was designed to be degraded through hydrolysis and enzymatic degradation mechanisms due to its ester bond along the polymer backbone. mPEG-PLA block copolymer was also synthesized by anionic ring opening polymerization of L-lactide onto mPEG (methoxy polyethylene glycol) to use for letting the interfacial layer stable. Using water-in-oil-in-water double emulsion technique, nanoparticles encapsulating water or fluorescein isothiocyanate were fabricated. The nanoparticles have PEG on their surfaces which helps nanoparticles to avoid the immune system. The morphology of these nanoparticles was characterized by DLS, TEM, FE-SEM and fluorescent microscopy. Encapsulation efficiency and in vitro drug release efficiency were also confirmed by UV/Vis spectroscopy.


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