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대한화학회 제122회 학술발표회 및 총회 NMR-based urinary profiling reveals different metabolic patterns in focal segmental glomerulosclerosis and minimal-change disease

등록일
2018년 8월 20일 21시 04분 58초
접수번호
0496
발표코드
ANAL.P-341 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 19일 (금요일) 11:00~12:30
발표형식
포스터 분석구두발표
발표분야
Analytical Chemistry
저자 및
공동저자
Jin Seong Hyeon, Geum-Sook Hwang*
Korea Basic Science Institute, Korea
Focal segmental glomerulosclerosis (FSGS) and a related disorder, minimal-change disease (MCD), are idiopathic glomerular disease related to podocytopathies. Although the renal biopsy is mandatory to confirm the diagnosis and guide therapeutic plans in patients with FSGS and MCD, biopsy is an invasive procedure affected by complications. We performed NMR-based urinary metabolic profiling analysis to investigate metabolic differences between FSGS and MCD. The PCA scatter plot showed a clear separation between FSGS and control groups. Moreover, MCD groups were slightly separated from FSGS groups. The significant metabolic alteration in FSGS and MCD groups compared to healthy control groups were related to tricarboxylic acid cycle, choline, and branched chain amino acid metabolism. Furthermore, metabolite that are significantly altered in the FSGS groups included alanine and lactate, whereas MCD groups contained 3-aminoisobutyrate. This study demonstrates that metabolic profiling is useful for understanding metabolic differences between FSGS and MCD patients, and diagnosing kidney disease.

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