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  • 09월 03일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Development of a multielement quantitation method from whole blood samples by ICP DRC MS

2018년 8월 21일 11시 45분 22초
ANAL.P-343 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 19일 (금요일) 11:00~12:30
Analytical Chemistry
저자 및
Yujin Lee, Eunji Seo, Sangwon Cha*
Department of Chemistry, Hankuk University of Foreign Studies, Korea
There are several attempts to assess all the environmental exposures of an individual and to reveal how the measured exposures affect to human health. Whole blood samples are one of the most widely used biomatrices for evaluating exposures due to their relatively easy accessibility. There have been many studies which tried to quantify elements from whole blood samples. Most of these studies focused on toxic heavy metals. For example, the US CDC laboratory manual published in 2014 described a method for quantitation of five toxic elements -cadmium, lead, manganese, mercury, and selenium- from whole blood samples. In this study, based on the US CDC laboratory manual, we tried to develop a multielement analysis method with whole blood samples that can cover up to about 15 elements including toxic heavy metals. To achieve this, we employed an efficient inductively coupled plasma (ICP) dynamic reaction cell (DRC) mass spectrometry (MS) platform with various cell gases. We also evaluated various sample preparation conditions and analysis parameters such as dilution factors, diluent compositions, cell gases, and cleaning procedures. In this presentation, we report the current progress in this development.