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제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Antiplatelet coating with poly((3-methacryloylamino)propyl-dimethyl(3-sulfopropyl)ammonium hydroxide) on titanium dioxide and stainless steel

등록일
2018년 8월 21일 15시 39분 53초
접수번호
0617
발표코드
MAT.P-353 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Material Chemistry
저자 및
공동저자
JiHwan Eom, Yeonwoo Jeong1, Sung Min Kang2, Woo Kyung Cho*
Department of Chemistry, Chungnam National University, Korea
1Department of Chemistry, Chungbuk Natioanl University, Korea
2Department of Chemistry, Chungbuk National University, Korea
When medical devices such as stent and catheter are inserted in blood vessel, platelet adhesion can cause a serious problem like blood coagulation, resulting in vascular clogging. To inhibit platelet adhesion on medical devices, in this work, we employed a zwitterionic material, (3-methacryloylamino)propyl)-dimethyl(3-sulfopropyl)ammonium hydroxide) (MPDSAH) by considering that zwitterionic polymers have antifouling effects by strongly stabilizing the hydration layer formed by aqueous solution. Titanium dioxide (TiO2) and stainless steel (SS), which are mainly used in medical devices, were chemically modified by surface-initiated atom transfer radical polymerization of MPDSAH. The surface-grafted polymeric films were characterized with ellipsometer, contact angle goniometer, X-ray photoelectron spectroscopy, and atomic force microscopy. Compared with bare substrates, the poly(MPDSAH)-coated substrates effectively reduced both fibrinogen and platelet adhesions. The platelet adhesion was reduced by 86% and 92% for the polymer-coated TiO2 and SS substrates, respectively.

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