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대한화학회 제122회 학술발표회 및 총회 An Analytical Method for Characterizing Naturally Occurring Compounds in Plants

등록일
2018년 8월 22일 11시 11분 31초
접수번호
0820
발표코드
ANAL.P-350 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 19일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
Analytical Chemistry
저자 및
공동저자
Su-Kyung Moon, Youjin Seo*
Analytical Research Center, Korea Institute of Toxicology, Korea
Naturally sourced chemicals produced by plants represent a viable source for compounds targeting various diseases and are widely used in products such as cosmetics, vitamins, and drugs. Sourcing these compounds relies on both robust extraction methods and accurate, reliable, scientific assays evaluating their purity, effectiveness, and toxicity. Herein, we report our assay aimed at measuring the compounds, chicoric acid and chrysophanol each derived from taraxacum officninale and cassis seed, respectively. Both these naturally occurring compounds have pivotal roles as antioxidants and are implicated in immunological disorders and atopic dermatitis. We developed an analytical method using a HPLC-UV platform assessing system suitability, linearity, specificity, accuracy, precision, homogeneity and carry-over. Our method accurately measured both compounds. In addition, our results matched the acceptance requirement of validation criteria established by ICH. This method provides a means to adhere to established guidelines and to levels of naturally occurring compounds derived from plants.

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