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  • 08월 30일 20시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Total synthesis of (±)-galanthamine and related natural products with the regioselective Pd-catalyzed coupling reactions of 3,5-dibromo-2-pyrone

등록일
2006년 9월 5일 10시 15분 19초
접수번호
1286
발표코드
29P299포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅱ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
류기문, 홍성초, 조천규
한양대학교 화학과,

Galanthamine is has potent inhibitory activity against acetylcholinesterase(Ache) in CNS. It significantly enhances cognitive functions of Alzheimer’s patients and has been approved for the treatment of AD in Europe and USA. Searching for more potent inhibitors of Ache, considerable effort is directed toward its synthesis and derivatization, as it is much less toxic than other inhibitors including physostigmine and tacrine. Envisioned that the cycloadduct of properly substituted 2-pyrone can readily provide the core structure of galanthamine, we set out to investigate the total synthesis of galanthamine, using the regioselective coupling reactions of 3,5-dibromo-2-pyrone and IMDA cycloaddition reactions as key steps.


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