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Synthetic and Biochemical Investigations Related to Cell Wall Polysaccharides from Mycobacterium tuberculosis

등록일
2007년 2월 5일 17시 34분 08초
접수번호
0052
발표코드
목16C1심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 14시 : 00분
발표형식
심포지엄
발표분야
유기화학 - Glycoscience: A New Frontier in Chemistry and Chemical Biology
저자 및
공동저자
T. L. Lowary
Department of Chemistry, The University of Alberta and The Alberta Ingenuity Centre for Carbohydrate Science, Gunning-Lemieux Chemistry Centre,
Mycobacterial diseases, such as tuberculosis and AIDS-associated Mycobacterium avium infections, are reemerging as worldwide health concerns, and their resurgence is providing significant motivation for the development of new anti-mycobacterial agents. A key structural component of the mycobacterial cell wall is arabinogalactan (AG), a polysaccharide composed almost exclusively of galactofuranose and arabinofuranose moieties. Another important cell wall polysaccharide is lipoarabinomannan (LAM), a major mycobacterial antigen, which is composed of arabinofuranose and mannopyranose residues. The enzymes that synthesize both polysaccharides are attractive drug targets, but much fundamental work on their biosynthesis and function much be carried out first. In this seminar, recent synthetic studies on various constituents of these cell wall polysaccharides will be presented as will investigations on the use of these compounds in understanding the biosynthesis and function of both AG and LAM.

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