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제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Electrochemical modification of diazonium for highly sensitive impedimetric DNA sensor

등록일
2018년 8월 30일 11시 52분 08초
접수번호
2029
발표코드
ELEC.P-502 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 19일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
Electrochemistry
저자 및
공동저자
Sujin Kang, Yang-Rae Kim1,*, Suseong Kim1
Kwangwoon University, Korea
1Department of Chemistry, Kwangwoon University, Korea
Electrochemical DNA sensors offer simple and rapid tools for detection of DNA sequences or damaged genes associated with human diseases. The performance of electrochemical DNA sensors is critically dependent on the process of the DNA immobilization. In this study, 4-nitrobenzenediazonium was chosen as a diazonium compound and electrochemically modified on a gold electrode. Unlike thiol-based self-assembled monolayers, electrochemical reduction of diazonium is a more selective and desirable strategy in a view of resistance to electrochemical perturbation and long-term stability. Then nitro group was converted into amino group through electrochemical reduction processes. After glutaraldehyde treatment, probe DNA sequence for Dengue virus was finally immobilized for detection of target DNA. All processes were electrochemically monitored using cyclic voltammetry and electrochemical impedance spectroscopy of ferri/ferrocyanide.

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