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제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis and photophysical study of 2-fluorenyl-1,2,3-triazole-labeled 2’-deoxyuridine, 2’-deoxyadenosine, 2’-deoxyguanosine, 2’-deoxycytidine, and their oligonucleotides

등록일
2018년 8월 30일 12시 32분 22초
접수번호
2032
발표코드
ORGN.P-253 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
SeungWoo Hong, Gil Tae Hwang*
Department of Chemistry, Kyungpook National University, Korea
Fluorene is a useful fluorophore because it has a good quantum yield and is less bulky than other commonly used fluorophore. Therefore we previously synthesized fluorene labeled 2’-deoxyuridine (UFL) through an ethynyl linker and observed good solvent dependent photophysical properties. In this study, we have synthesized triazole-linked fluorenyl 2’-deoxyuridine (UFT), 2’-deoxyadenosine (AFT), 2’-deoxyguanosine (GFT), 2’-deoxycytidine (CFT) through copper catalyzed azide-alkyne cycloaddition (CuAAC). All four modified nucleosides displayed different fluorescence intensities and emission maxima in different solvents, indicating its potential for application as an environmentally sensitive probe. In addition, we inserted UFT, AFT, GFT, and CFT at the central position of an oligonucleotides (ODNs). Herein the photophysical properties of fluorene-labeled nucleosides with a triazole linker and their corresponding ODNs will be discussed.

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