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제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis and biological effects of hydrogen sulfide donor peptide hybrids.

등록일
2018년 8월 30일 13시 55분 26초
접수번호
2048
발표코드
MEDI.P-323 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Medicinal Chemistry
저자 및
공동저자
Clovis Shyaka, Chung-Min Park1,*
Chemistry, Gangneung-Wonju National University, Korea
1Chemical Advanced Materials, Gangneung-Wonju National University, Korea
Hydrogen sulfide (H2S) has been known as a critical signaling molecule that regulates many physiological and/or pathological processes. With the multiple biological actions of H2S, there is growing interest in developing various H2S-releasing compounds for precise delivery of the gas to target tissues. Recently, the connection between drug and H2S-delivery components has led to a considerable variety of H2S donors with potential therapeutic effects against diseases. In our group, hydrogen sulfide (H2S)-releasing dithiolethione (ADT) functionalized with biologically active peptides are being investigated for their integrated anti-inflammatory and antioxidant potential. Herein, we report the synthesis of a series of H2S-releasing compound peptide hybrids and their initial biological effects.

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