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제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 S-thiotrialkylsilyl cysteines: Novel persulfide precursors for exploring of cysteine posttranslational modifications

등록일
2018년 8월 30일 14시 19분 44초
접수번호
2052
발표코드
ORGN.P-256 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Yu Rim Kwon, Sol Ryeong Im1, Chung-Min Park2,*
Department of Chemistry, Gangneung-Wonju National University, Korea
1Department of Chemical Advanced Materials, Gangneung-Wonju National University, Korea
2Chemical Advanced Materials, Gangneung-Wonju National University, Korea
Persulfides (RSSH) have been known as important components along with hydrogen sulfide (H2S) and hydrogen polysulfides (H2Sn) in sulfur-mediated redox cycles and involve in cell signaling. However, the study of persulfide chemistry remains a challenge because of the lability of the RSSH compounds and a lack of efficient precursors. Reported here is the synthesis and evaluation of S-thiotrialkylsilyl (R’SSSiR32) compounds as potential persulfide precursors. The compounds are moisture-stable and undergo desilylation with fluoride ions to release of the corresponding persulfides. In addition, we will discuss that pH-dependent hydrolytic removal of various silyl groups on the persulfide precursors releases the corresponding persulfides in control fashion.

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