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제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Facile and rapid synthesis of dehydroalanines from S-thiotrialkylsilyl cysteines

등록일
2018년 8월 30일 14시 21분 38초
접수번호
2057
발표코드
ORGN.P-257 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Sol Ryeong Im, Yu Rim Kwon1, Chung-Min Park2,*
Department of Chemical Advanced Materials, Gangneung-Wonju National University, Korea
1Department of Chemistry, Gangneung-Wonju National University, Korea
2Chemical Advanced Materials, Gangneung-Wonju National University, Korea
The α,β-unsaturated amino acids (dehydroalanines) are found in a variety of biological peptides and natural products. Synthetically, they can be versatile precursors to unnatural amino acids which can be used to alter the structural properties of peptides. The synthesis of dehydroalanines has previously been achieved by many different methods. However, most procedures are not selective or are incompatible with other amino acid residues in the peptide or require many steps and long reaction time. Reported in this work is the rapid synthesis of dehydroalanines from S-thioalkylsilyl cysteine derivatives under mild reaction conditions. The cysteine residue in peptides can be easily functionalized to S-thiotrialkylsilyl moiety and they are subsequently and conveniently converted into the corresponding dehydroalanines at the desired position.

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