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제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis and fluorescence property analysis of 2'-deoxyuridines labeled with fluorene directly or diacetylenyl linker and their corresponding oligonucleotides

등록일
2018년 8월 30일 16시 29분 31초
접수번호
2122
발표코드
ORGN.P-272 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
So Young Lee, Gil Tae Hwang*
Department of Chemistry, Kyungpook National University, Korea
Fluorescent nucleoside analogs that are sensitive to their local environment, demonstrating changes in the fluorescent properties when induced by changes in polarity, pH, or even structure, have become powerful tools for the investigation of nucleic acid structure, dynamics, and recognition. Therefore we previously synthesized the fluorene-linked 2’-deoxyuridine through the Suzuki coupling of 5-iodo-2’-deoxyuridine with fluorene 2-boronic aicd pinacol ester. In this study, we synthesized fluorene-labeled 2’-deoxyuridine via a diacetylenyl linker and investigated its solvent-dependent photophysical properties. In addition, we incorporated it into the central position of oligodeoxynucleotide to investigate the potential as a SNP probe upon the duplex formation with fully matched and single-base mismatched targets. Detailed research results including these will be presented.

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