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제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Inorganic-Organic-Polymer Hybrid Bead as the Nutraceutical supplement with Essential Minerals and Vitamin

등록일
2018년 8월 30일 17시 06분 50초
접수번호
2141
발표코드
MAT.O-13 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 10시 : 24분
발표형식
구두발표
발표분야
Material Chemisty - Oral Presentation of Young Material Chemists
저자 및
공동저자
HyeonJu Ryu, Goeun Choi, Jin-ho Choy*
Department of Chemistry and Nano Science, Ewha Womans University, Korea
We have designed and prepared a new hybrid composed of calcium alginate and metal hydroxide containing Mg2+, Zn2+, and Cr3+ as a mineral supplement for diabetic patients according to the recommended daily intake of nutrient minerals by FDA. As well documented, the deficiency of essential minerals such as Ca2+, Mg2+, Zn2+ and Cr3+, and vitamin B6 (VB6) are causing various new cases of diabetes mellitus type II. So attempts have been made to prepare a mixed metal hydroxide (MMH) containing essential mineral ions by co-precipitation method. And it was then further dispersed in an aqueous solution of alginate containing VB6, and thus prepared suspension was finally added to an aqueous solution of CaCl2 to form calcium alginate bead hybridized with MMH nanoparticles and VB6 as the final product (VB6-MMH-calcium alginate). The chemical formula of MMH was determined to be Mg0.988Zn0.011Cr0.001(OH)2 as confirmed by ICP-AES analysis, which was well consistent with the theoretical one. According to the SEM and EDS studies, the crystal structure and shape of MMH nanoparticles were found to be thin and plate-like with a homogeneous size distribution of ~100 nm, those which were rather uniformly distributed in the beads. According to the in-vitro release profiles, the VB6 molecules from VB6-MMH-calcium alginate bead were released out only 37.8 % after 2 hours at pH 1.2, but ~80 % within 2 hours at pH 6.8, and gradually reached to ~98 % after 6 hours due to the pH dependent swelling behaviour of alginate polymer. In addition, the chemical stability test for intact VB6 and VB6-MMH-calcium alginate bead was also performed at 25 ± 2 °C in 60 ± 5 % humidity for 2 months based on the guideline of Korean FDA. After 2 months exposure, the VB6 content for the former was strongly reduced down to 30 %, but that for the latter was remained almost unchanged to be 97 % indicating its enhanced stability. Therefore, we suggest that the present hybrid system, VB6-MMH-calcium alginate bead, can be an excellent nutraceutical supplement for diabetic patients.

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