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제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Biocompatible Nanohybrid Fiber Formation of Polyvinyl alcohol (PVA)/ Poly(acrylic acid) (PAA)/ Layered double hydroxides under Various Electrospinning Conditions

2018년 8월 31일 11시 17분 08초
MAT.P-482 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 18일 (목요일) 11:00~12:30
Material Chemistry
저자 및
Ji Hee Lee, Goeun Choi1, Jin-ho Choy1,*
Chemistry Department of Nano-Science, Ewha Womans University, Korea
1Department of Chemistry and Nano Science, Ewha Womans University, Korea
At first, the formation of nanofibers with poly(vinyl alcohol) (PVA)/layered double hydroxide (ZnAl LDH, ZnCuAl LDH) composites were examined by electrospinning method with an applied potential of 19 kV. Either inorganic colloidal LDH (C-LDH) or powder LDH (P-LDH) was used for incorporating with PVA in an aqueous solution. Scanning electron microscopy (SEM) images for thus prepared fibers suggested that C-LDHs were better dispersed than P-LDH within PVA matrix without forming any aggregates, but with a small content of beadings formation. This is surely due to the fact that P–LDH nanoparticles were not dispersed completely and eventually conglomerated in the PVA matrix. In the present study, therefore, all the PVA/C-LDH fibers were further developed by adding poly(acrylic acid) (PAA) solution in order to enhance the chemical interaction between LDH and polymers, and by changing the synthetic parameter like the content of C-LDH in order to escape from the formation of beadings. Since PAA is a hydrophilic polymer, it can easily be incorporated with PVA one to form hybrid fibers due to an enhancement of hydrogen bonding interaction between them and also with LDH, as well. As expected, PVA/PAA/C-LDH fibers were well prepared without forming any aggregates and beadings, due to an enhanced dispersion of LDH nanoparticles in the PVA/PAA matrix and as a consequence, its electrospinnability was improved. The cytotoxicity of PVA/PAA/C-LDH (ZnAl LDH, ZnCuAl LDH) nanofibers was evaluated on the basis of an indirect cytotoxicity assay after the cells were cultured with the extracted media from nanofibers for 48h. PVA/PAA/C-ZnAl LDH nanofibers showed more than 80 % cell viability enough to be used as non-toxic and biocompatible materials.