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제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Paracellular Transport Behavior of Negatively Charged 2D Nanoparticles Based on In-Vitro Follicle Associated Epithelial Model

2018년 8월 31일 16시 02분 13초
MAT.P-483 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 18일 (목요일) 11:00~12:30
Material Chemistry
저자 및
Jiyeong Kim, Goeun Choi1, Jin-ho Choy1,*
Chemistry Department of NanoScience, Ewha Womans University, Korea
1Department of Chemistry and NanoScience, Ewha Womans University, Korea
Oral drug delivery is the most common route for drug administration due to its safety and convenience. One of various oral drug delivery vehicles, anionic clay, such as layered double hydroxides (LDHs), has been attracted a great deal of attention due to its high biocompatibility, high drug loading capacity and controlled release property. In this study, in-vitro human Follicle-associated epithelium (FAE) model was used to understand the transport pathways of 2D nanoparticles with respect to their particle sizes from 100nm to a few ㎛, how they could be translocated across the cellular monolayer. A decrease in transepithelial electrical resistance (TEER) for the Caco-2 and Raji B co-cultured monolayers incubated with LDH nanoparticles indicated that the paracellular tight junctions became loosened. We also found that the paracellular transport of nanoparticles was size-dependent, and that the 100nm sized LDH showed better translocation than the other sized. It is, therefore, concluded that the present 2D nanoparticles were translocated through paracellular transport pathway as well confirmed by the confocal images of co-culture cell monolayer.