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  • 09월 03일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Heterometallic BODIPY-Based Molecular Squares obtained by Self-assembly: Synthesis and Biological Activities

2018년 9월 3일 17시 32분 47초
INOR.P-187 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 19일 (금요일) 11:00~12:30
Inorganic Chemistry
저자 및
Yeji You, Gajendra Gupta1, Chang Yeon Lee1,*, Dong-Ku Kang*
Department of Chemistry, Incheon National University, Korea
1Department of Energy and Chemical Engineering, Incheon National University, Korea
Metal-based multinuclear supramolecules of different functionality designed by self-assembly process has been a growing area of research due to their versatile applications. Four new bodipy based octacationic heterometallic molecular squares 3-6 were synthesized by self-assembly processs by reaction of dipyridyl bodipy ligands with suitable 90º palladium and platinum acceptors. The formation of the as-synthesized molecular squares were confirmed by different analytical techniques using multinuclear NMR spectroscopy, elemental analysis, high resolution elctrospray mass spectrometry (HR-ESMS), UV/Vis and PL spectroscopy. The cytotoxicty of the new supramolecules and the starting precursors were studied against colorectal carcinoma (HCT116), prostrate adenocarcinoma (PC-3), breast adenocarcinoma (MCF-7), lung adenocarcinoma (A549) and non-malignant human kidney epithelial (HEK-293) cell lines using MTT assay. To determine the intracellular localization of supramolecules, their auto-fluorescence was a good tool for searching supramoelcules. The cell death action mechanism of supramolecules was identified with two cell lines that had good cytotoxicity activity were stained with FITC conjugated Annexin-Ⅴ and propidium iodide (PI).