KCS

Ecklonia cava is a sort of brown algae native to Korea and Japan, containing unique polyphenols referred to as phlorotannins. Recently, several studies have been examined the effect of phlorotannins, which reduces body fat and improves cardiovascular function. However, there are few metabolic studies relevant to those effects in human model. In this study, we performed a comprehensive metabolomics analysis of urine from males and females with a BMI over 25kg/m2 and under 30kg/m2 using ultra-performance liquid chromatography quadruple time-of-flight mass spectrometry (UPLC-Q-TOF-MS) to investigate effects of Ecklonia cava extract (Seapolynol) intake on the exogenous and endogenous metabolites. Statistical anaylsis were performed with correlation analysis and Hierarchical clustering analysis. We found that several endogenous and exogenous metabolites were significantly associated with Seapolynol intake, such as sulfonic acid, organic acid, xanthine and flavonoid glycoside. Especially, the levels of methyl xanthine and methyl uric acid were increased, whereas flavonoid glycoside was decreased in Seapolynol group. This study demonstrates that UPLC / MS based urine metabolic approach can be used to investigate the metabolic effects of Seapolynol intake and provide the insight for metabolism.