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  • 09월 03일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제122회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Low-cost plastic devices for drug-resistant pathogen detection in point-of-care setting

2018년 8월 23일 14시 44분 09초
ANAL2.O-8 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 09시 : 55분
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
저자 및
Jihyo Park, Seonki Hong*
Department of Emerging Materials Science, Daegu Gyeongbuk Institute of Science & Technology, Korea
World health organization (WHO) warns against ‘post-antibiotic’ era as a consequence of the rapid emergence of drug-resistant pathogens, so called superbugs, that are not treated by most of antibiotics. Advanced diagnostic techniques allow clinicians to prevent inappropriate prescribing and overuse of antibiotics which may delay the emergence of life-threatening pathogens. In this study, we aim to develop a low-cost plastic device for rapid and accurate pathogen detection. We applied a nature-inspired material-independent biosilicification process on the surface of plastics that is difficult to be functionalized by conventional surface chemistry due to intrinsic hydrophobicity and lack of functional groups for bioconjugation. By this approach, the surface of polycarbonate and polypropylene-based plastic devices with micro-pillar structure were successfully decorated by silica so that we could selectively enrich bacterial RNA from whole lysate on the surface of devices. Surface-enriched RNA was further detected by on-chip colorimetric loop-mediated isothermal amplification (LAMP) within 30 minutes.