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  • 02월 28일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제123회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Trans-activator of transcription peptide coated ultrasmall Gd2O3 nanoparticles

등록일
2019년 1월 24일 16시 50분 23초
접수번호
2811
발표코드
PHYS.P-88 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 19일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
Physical Chemistry
저자 및
공동저자
Shuwen Liu, Gang Ho Lee1,*
Department of Chemistry, Kyungpook National University, China
1Department of Chemistry, Kyungpook National University, Korea
Gadolinium oxide nanoparticles are extremely useful for biomedical applications because they possess various excellent physical properties which is applicable to cancer theragnosis. In this study, we prepared gadolinium oxide coated with trans-activator of transcription through one-pot process. We characterized the particle size, surface coating structure, relaxivities an in vitro toxicities of the TAT-GNPs. The average particle diameter is obtained to be 1.5 nm. The r1 and r2 values of the TAT-GNP are 18.2 and 30.2 s-1mM-1 (r2/r1=1.6). The in vivo T1 MR images exhibited positively (or T1) enhanced contrasts in the mouse liver cancer after intravenous administration, demonstrating that the TAT-GNPs acted as an enhanced cancer-imaging agent similar to the cancer-targeting agent in T1 MR imaging (T1 MRI).

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