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  • 02월 28일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제123회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Water Soluble Polyacrylic acid Coated Tb2O3 Nanoparticles as Dual Imaging Agent: T2 MRI-Fluorescence Imaging Agent

2019년 1월 28일 17시 20분 09초
PHYS.P-91 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 19일 (금요일) 11:00~12:30
Physical Chemistry
저자 및
Shanti Marasini, Gang Ho Lee1,*
Department of Chemistry, Kyungpook National University, Nepal
1Department of Chemistry, Kyungpook National University, Korea
Surface modification of nanoparticles with multifunctional hydrophilic polymer has been proved as a major achievement in synthesis of highly colloidal and biocompatible magnetic nanoparticles. These polymers render magnetic nanoparticles more stable, water soluble and uniform which makes it easier for post synthesis modification and functionalization for bio-applications such as drug delivery, magnetic resonance imaging, cell targeting and hyperthermia. Here, we present the synthesis of ultrasmall Terbium oxide nanoparticles coated with water soluble and biocompatible Polyacrylic acid (PAA~1800 gm/mol) using polyol method. Nanoparticles were characterized by measuring their particle diameter, hydrodynamic diameter, surface coating, magnetic moment (M), r1 and r2 values, map images, and in vitro cellular toxicity using different characterization techniques. The fluorescence property was studied through photoluminescence spectrometry and confocal laser scanning microscopy. In vivo MR images were recorded which shows the negative contrast enhancement on liver and kidney after 15 minutes of injection. Hence it can be inferred that ultrasmall Tb2O3 nanoparticles can be used as T2-FI imaging agent.