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  • 02월 28일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제123회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Carbon-coated gadolinium oxide nanoparticles for dual-modal imaging

2019년 2월 1일 13시 35분 37초
PHYS.P-99 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 19일 (금요일) 11:00~12:30
Physical Chemistry
저자 및
Huan Yue, Gang Ho Lee*
Department of Chemistry, Kyungpook National University, Korea
In this study, we synthesized fluorescence and magnetic resonance dual-modal imaging carbon-coated gadolinium oxide nanoparticles with a good biocompatibility and non-toxic through a facile one-pot process in a solution. The mild synthesis route improves optical properties and the stability of well-defined core-shell structured Gd3+ chelated-conjugated carbon nanoparticles. Besides, the carbon-coated gadolinium oxide nanoparticles have a narrow size distribution in the range of 3nm±2nm. In vitro non-toxic confirmed by both DU145 and NCTC1469 cell lines, as well as water proton relaxivity and in vivo MRI of the carbon-coated gadolinium oxide nanoparticles shown a high longitudinal. The products can be used as T1 MRI contrast agent. The optical properties were investigated by Confocal Laser Scanning Microscope at 525nm, the thin carbon layer on the surface of gadolinium oxide nanoparticles showed green color, and under the irradiation of UV light at 365 nm, the carbon nanoparticles showed sky-blue color. As a result, it indicated that the carbon-coated gadolinium oxide nanoparticles can be used as dual mode MR and fluorescence imaging.