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학술발표회초록보기

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  • 02월 28일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제123회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Cellular cytosol-penetrating antibody technology and its applications

등록일
2019년 2월 12일 13시 19분 32초
접수번호
3917
발표코드
LIFE1-2 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 16시 : 10분
발표형식
심포지엄
발표분야
Life Chemistry - Recent Trends in Biopharmaceuticals Research
저자 및
공동저자
Yong-Sung Kim
Department of Applied Chemistry & Biological Engineering, Ajou University, Korea
Our group recently developed a platform technology of cellular cytosol-penetrating antibody (cytotransmab), which in the IgG format can reach the cytosolic space of living cells owing to its endosomal escaping ability after receptor-mediated endocytosis. Based on the cytotransmab technology, we have engineered human IgG1 format antibody, named iMab, which specifically internalizes into the cytosol of tumor cells and then selectively binds to targeted cytosolic proteins, including oncogenic Ras mutants. In this talk, I will present an innovative antibody technology that directly targets intracellular oncogenic KRas mutants to block the function from outside of cells after systemic administration. Our studies also demonstrate the feasibility of developing antibody therapeutics that directly target cytosolic proteins involved in disease-associated protein-protein interactions.

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