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제123회 대한화학회 학술발표회, 총회 및 기기전시회 안내 A New Infrared Probe Targeting Mitochondria via Regulation of Molecular Hydrophobicity

등록일
2019년 2월 14일 14시 15분 48초
접수번호
4422
발표코드
ORGN.P-331 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 18일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Eunha Kim*, Jun-Sik Min1
Department of Molecular Science and Technology, Ajou University, Korea
1Molecular science and technology, Ajou University, Korea
The morphology of the mitochondria is affected by cell function and disease state. Recent studies indicated that the morphology of the mitochondira can be utilized as a biological marker for the diagnosis of cancer phenotypes and to monitor drug response. So the demand for fluorescent mitochondrial bioprobes has been increasing. For the efficient transfer of probe molecules through lipid bilayers and their accumulation in the mitochondrial matrix, most fluorescent bioprobes targeting mitochondria are based on compound conjugation with lipophilic cations (typically triphenyl phosphonium ion). Herein, using 10 commercial amines as additives to modify the hydrophobicity of Si-R fluorescent cores, we have developed near-infrared (NIR) fluorescent probes for mitochondrial staining. In this context, we reasoned that systematic modification of fluorophore hydrophobicity could provide an excellent guide for future development of efficient and versatile mitochondrial fluorescent probes.

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