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제123회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Asymmetric Synthesis of β-Amino Alcohols using Acrolein Derivatives

등록일
2019년 2월 14일 14시 13분 56초
접수번호
4429
발표코드
ORGN.P-332 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 18일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Jae-Yeon Kim, Do Hyun Ryu*
Department of Chemistry, Sungkyunkwan University, Korea
β-Amino alcohols are useful in organic synthesis and medicinal chemistry due to its biological activities such as antibacterial and anti-tuberculosis activities.1 Recently, β-amino alcohols are used as active pharmaceutical ingredients (API) such as adrenergic agonists,2 and HIV protease inhibitors.3 Generally, β-amino alcohols are good substrates for chiral ligands or chiral auxiliaries in organic synthesis.4 Due to its synthetic utility, development of new synthetic methods to prepare those compounds has been an active area of research.5 In this research, we synthesized highly optically active β-amino alcohol derivatives with good yields (up to 95%) and high enantioselectivities (up to 98% ee) from simple acrolein compounds catalyzed by chiral boron catalyst via single electron transfer mechanism.

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