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  • 02월 28일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제123회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Regioselective Synthesis of Functionalized 4-Pyrones by Thermal Wolff-Rearrangement

등록일
2019년 2월 14일 15시 02분 08초
접수번호
4482
발표코드
ORGN.P-342 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 18일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Hyewon Kim, Yong Rok Lee1,*
Chemical Engineering, Yeungnam University, Korea
1Division of Chemical Engineering, Yeungnam University, Korea

4-Pyrones (γ-Pyrones) are important oxygenated heterocyclic compounds that are found widely in nature. Various 4-pyrones are known to possess biological activities, acting as anticancer, antifungal, antibacterial, insecticidal, and immunosuppressive agents. Hence, members of this class have been evaluated and utilized as drug molecules. These compounds have been also used as valuable building blocks for the construction of bioactive natural products. Owing to their importance and usefulness, various methods have been demonstrated for their construction. Although a number of methods for the synthesis of substituted 4-pyrones have been reported, more facile and efficient protocols are still highly desirable. In our continued efforts to develop new synthetic methodologies based on the Wolff rearrangement, we have been investigating transition-metal-free thermal cascade reactions of diazodicarbonyl compounds and β-enamino esters or β-enamino ketones. Herein, we report on a novel and direct regioselective construction of diverse 3-carbonyl functionalized 4-pyrones via thermal Wolff-rearrangement of diazodicarbonyl compounds.


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