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제123회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Strange Cargo Delivery Dynamics in Living Cells

2019년 2월 14일 15시 12분 52초
PHYS.P-207 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 19일 (금요일) 11:00~12:30
Physical Chemistry
저자 및
Kyujin Shin, Sanggeun Song1, Ji-Hyun Kim1, Jaeyoung Sung1,*, Kang Taek Lee2,*
Department of Chemistry, Gwangju Institute of Science and Technology, Korea
1Department of Chemistry, Chung-Ang University, Korea
2Division of Physical Chemistry Department of Chemi, Gwangju Institute of Science and Technology, Korea
Vesicle-transport conducted by motor-protein-multiplexes, ubiquitous among eukaryotes, shows mysterious stochastic dynamics, qualitatively different from dynamics of thermal motion and artificial active matter; the relationship between in vivo vesicle-delivery dynamics and dynamics of the underlying physicochemical processes is not yet quantitatively understood. Addressing this issue, we perform accurate, label-free tracking of individual vesicles, containing probes free of photobleaching or photoblinking, transported by kinesin-dynein-multiplexes along axonal microtubules in human neuroblastoma cells. The mean-square-displacement of vesicles along the microtubule exhibits unusual dynamic phase transitions, seemingly inconsistent with the scaling behavior of the mean-first-passage time over the travel length. These paradoxical results and the vesicle displacement distribution at all times are quantitatively explained and predicted by a multi-mode motor multiplex model where ATP-hydrolysis-coupled motion of kinesin-dynein-multiplexes has both unidirectional and bidirectional modes. This work presents a new paradigm of quantitative biology, ushering in a new age of quantitatively understanding and predicting mysterious biological phenomena through the analytical power of mathematical deduction informed by physics and chemistry.