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02월 28일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능
제123회 대한화학회 학술발표회, 총회 및 기기전시회 안내
Profiling of lipoproteins from post-menopausal patients with osteoporosis by asymmetrical flow field-flow fractionation and nUHPLC-ESI-MS/MS
2019년 2월 7일 15시 54분 05초
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목 09시 : 32분
Analytical Chemistry -
Oral Presentation of Young Analytical Chemists I
Kang Geun Lee
, Joon Seon Yang
, Myeong Hee Moon
Department of Chemistry, Yonsei University, Korea
The Resource Center for Stable Isotope-Resolved Metabolomics, University of Kentucky, United States
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Pathological mechanism of osteoporosis is not clearly known, but osteocytes affected by oxidized lipids are expected to be one of major factors. Bone mineral density (BMD) reaches the highest level in the age of 30s and decreases slowly over time, but symptoms are scarcely detected and it already gets serious when found out. Lipids play important roles in signal transduction, cell formation and various cellular processes. therefore, they are expected to be possible biomarkers to several diseases. Therefore, it is important to study relationships between lipids consisting lipoproteins in plasma and osteoporosis for early diagnosis. There are several studies about the relationship between lipids and osteoporosis in which BMD showed a meaningful correlation with low-density lipoprotein (LDL) and high-density lipoprotein (HDL). However, none of them conducted quantitative and qualitative analysis by using mass spectroscopy to differentiate lipid species at the molecular level in detail. In this study, 39 female plasma samples were classified into three groups : women having osteoporosis with no history of other diseases (n=10), women having osteoporosis with history (n=7), and age-matched control (n=22). Flow field-flow fractionation (FlFFF) is a technique that can separate particles or macromolecules by size. Lipoproteins of blood samples were fractionated by sizes using asymmetrical flow field-flow fractionation and the lipids were analyzed by nanoflow ultrahigh-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (nUHPLC-ESI-MS/MS). Overall, 341 lipids from patient’s plasma were identified and 289 lipids were quantified with statistical evaluations for the screening species with significant alterations when osteoporosis was developed.
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