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  • 02월 28일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제123회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Proteomics Approach for Plasma Exosomes in Lung Cancer Patients

등록일
2019년 2월 12일 11시 16분 39초
접수번호
5008
발표코드
ANAL1.O-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 09시 : 12분
발표형식
구두발표
발표분야
Analytical Chemistry - Oral Presentation of Young Analytical Chemists I
저자 및
공동저자
Jihoon Shin, Jinwook Lee, Min-gyu Youn, Miseon Jeong, Junghoon Kang, Wonryeon Cho1,*
Department of Chemistry, Wonkwang University, Korea
1Department of Bio-nanochemistry, Wonkwang University, Korea
Exosomes are cell-derived nanovesicles that are rich source of novel biomarkers in the diagnosis and prognosis of disease. Exosomes have highly-specialized functions and play a key role in processing intercellular signaling. They are present in many complex biological fluids such as plasma. This study intends to identify exosome biomarker from lung cancer plasma. Exosomes were individually extracted from 46 patients’ plasma of lung cancer through size-exclusion chromatography. Each exosome sample was pooled into three TNM groups. Each group of exosome samples from lung cancer patients was lysed with RIPA buffer. After Lysis, separated proteins from exosome were trypsin digested. Each group samples were identified nLC-MS/MS using Orbitrap Elite multiple times with various methods for exosomal protein identification from lung cancer plasma.

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