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  • 02월 28일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제123회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Detection of C18-ceramide through a novel µPAD coupled with mass spectrometry

2019년 2월 13일 11시 52분 43초
ANAL1.O-22 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 10시 : 24분
Analytical Chemistry - Oral Presentation of Young Analytical Chemists I
저자 및
Shavkatjon Azizov, Sharipov Mirkomil, Salah Mahmoud Tawfik Ahmed, Huy B.t., Huy B.t., Yong-ill Lee*
Department of Chemistry, Changwon National University, Korea
We developed an innovative wax-printed microfluidic paper-based analytical device (µPAD) coated with paraffin has been as a highly efficient and low-cost microfluidic device resistant to common mass spectrometry organic solvents. The prepared novel µPAD-MS system has been introduced for the analysis of C18-ceramide through complexation with metal ions. In contrast to simple paper spray system, the developed µPAD has allowed the analysis of low concentration of C18-ceramide due to the maximum supply of deposited analyte through a microchannel. The MS results established the formation of doubly and singly charged metal ion complexes between ceramide and different metal ions. Especially, the complexation that occurs between lithium ions and C18-ceramide showed a high relative abundance over other formed complexes. The established µPAD has shown its prospective in the analysis of hydrophobic biomolecules dissolved in organic solvents and at the same time to avoid their penetration through the developed barriers. The developed µPAD-MS technique provides clear advantages over the other methods by reducing the number of experimental steps and simplifying the operation process for the identification of C18-ceramide.