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  • 02월 28일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제123회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Nonionic alginate-coated upconversion nanoparticles functionalized with folic acid for selective NIR-imaging and pH-responsive drug delivery

2019년 2월 13일 12시 23분 18초
ANAL1.O-19 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 10시 : 12분
Analytical Chemistry - Oral Presentation of Young Analytical Chemists I
저자 및
Sharipov Mirkomil, Salah Mahmoud Tawfik Ahmed, Huy B.t., Yong-ill Lee*
Department of Chemistry, Changwon National University, Korea
Rare-earth upconversion nanoparticles (UCNPs) have been proposed as biological luminescent labels for the bioimaging application of future because of their property to convert NIR irradiation to visible light. However, their toxicity, low dispersion, and low selectivity call into question their suitableness in nanomedicine. To address these challenges, naturally modified nonionic alginate-based polymers were successfully synthesized and coated onto upconversion nanoparticles (UCNPs) to act as functionalizing agents. The developed hybrid polymer-UCNPs nanoparticles have showed a high stability and excellent biocompatibility. These hybrid nanoparticles have shown a selective NIR imaging of KB cells due to the presence of folic acid. Moreover, the presence of large cavities of materials and amphiphilic polymer shell, these hybrid nanoparticles were able to efficiently load the anticancer drug doxorubicin (DOX) as well as to release it in highly controlled and selective manner via folate receptor-mediated endocytosis. Cytotoxicity test against KB cells have confirmed that hybrid nanoparticles loaded with DOX have a higher inhibition of growth of KB cells compared to free DOX. The developed theranostics platform is capable to simultaneously perform imaging and deliver anticancer drugs and thereby is expected to grant a valuable innovation in bioimaging and nanomedicinal applications.