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  • 02월 28일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제123회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Feasibility of electrochemically modulated SERS measurement for improved differentiation of gallbladder diseases

등록일
2019년 2월 9일 13시 31분 01초
접수번호
5114
발표코드
ANAL2.O-9 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 09시 : 32분
발표형식
구두발표
발표분야
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
저자 및
공동저자
Tung Vu, Eunjin Jang1, Hoeil Chung*
Department of Chemistry, Hanyang University, Korea
1Chemistry, Hanyang University, Korea
A screen-printed electrode (SPE) covered with three-dimensional gold nanodendrites (AuNDs) was used to measure SERS spectra of bile juices. To acquire SERS spectra with distinct features, a bile juice was pretreated with CH3Cl-CH3OH solution to eliminate hydrophobic components such as lipids and the remained aqueous hydrophilic phase was measured. Interestingly, Raman spectral features of the aqueous phase samples mostly resembled with those of bilirubin. So, it was presumed that the peaks were originated from conjugated-bilirubins, formed in a liver by attachment of sugars (such as glucuronic acid) to bilirubin (a heme break down product). Subsequently, conjugated-bilirubin becomes soluble in water. It expects that structure and composition of conjugated-bilirubin are dissimilar depends on different GB diseases (GB stone, polyp and cancer). Further, potentially improve the differentiation, varying electrochemical potentials were applied to the bile juice sample on SPE surface and corresponding SERS spectra were also acquired. Finally, principal component analysis (PCA) was used to qualitatively evaluate the degree of discrimination among these 3 GB diseases in the cases with and without application of electrochemical potential.

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