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학술발표회초록보기

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  • 02월 28일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제123회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Metabolomic analysis of human blood associated with ambient particulate matter in air pollution

등록일
2019년 2월 14일 17시 02분 56초
접수번호
5125
발표코드
ANAL2.O-19 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 10시 : 12분
발표형식
구두발표
발표분야
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
저자 및
공동저자
Seoyoung Jang, Geum-Sook Hwang*
Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute, Korea
Ambient particulate matter (PM) has became the major environmental risk factors in Korea, and exposure to PM is associated with adverse health effects on human. The objective of this study was to assess the alteration in response to environmental exposure and to investigate the association between levels of metabolite identified in human whole blood samples and PM with a diameter 2.5-10 µm(PM10).
In this study, we analyzed human whole blood from 457 Koreans using 1H-NMR spectroscopy. The concentration of PM10 was used in multivariate linear regression model adjusted for age, sex, BMI, and smoking status. We found that PM10 was significantly related to energy metabolism such as lactate, pyruvate, glucose, and fumarate.
This approach can be a novel tool to identify potential biomarkers for predicting exposure of pollutants like PM10 and to assess the impacts of environmental pollution on human metabolism.

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