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02월 28일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능
제123회 대한화학회 학술발표회, 총회 및 기기전시회 안내
Metabolic profiling of plasma and urine from a randomized trial on the effects of dietary patterns.
2019년 2월 14일 17시 19분 32초
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금 10시 : 08분
Analytical Chemistry -
Oral Presentation of Young Analytical Chemists II
, Do Hyun Ryu
, Geum-Sook Hwang
Korea Basic Science Institute, Korea
Department of Chemistry, Sungkyunkwan University, Korea
Habitual diet plays an important role in the metabolic profile and composition of the gut microbiota that can affect the host. To investigate the potential benefits of the Korean diet which is plant-based diet compared to western diet, we analyzed the changes of metabolites and gut microbiota after Korean diet (KD), the 2010 Dietary Guidelines for Americans (DGAD), and a typical western diet (WD). In a three-period crossover trial, 55 subjects were randomly assigned to one of six possible sequential orders for eating each diet (KD, DGAD, and WD) for 4 weeks, separated by a 2-week rest. Samples were collected before and end of each diet period. Using 1H NMR and 16S rRNA-targeted sequencing, metabolites and gut microbiota were profiled. Multivariate analysis showed discriminated metabolic pattern between before and after samples in every diet. Pathway analyses revealed that the most enriched metabolic pathway was valine, leucine and isoleucine biosynthesis in KD; synthesis and degradation of ketone bodies in DGAD and WD. Particularly, KD decreased plasma branched-chain amino acids (BCAA), such as leucine, isoleucine, and valine, which is related to obesity metabolism. Whereas DGAD and WD increased plasma ketone bodies, such as acetate, 3-hydroxybutyrate, 2-aminobutyrate, and acetone related to lipid metabolism. Also, in correlation analysis of metabolome and gut microbiota, plasma BCAAs were negatively correlated with Bifidobacterium only after KD intervention. Trimethylamine N-oxide, betaine, and choline were positively correlated with gut microbial lipid metabolism only after WD intervention. This study demonstrates that the analysis of the host metabolism and gut microbiota provide insight into the relationship between dietary patterns and risk of metabolic disease.
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