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  • 02월 28일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제123회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Optical analysis of degree of deacetylation in chitosan

2019년 2월 20일 12시 37분 39초
ANAL2.O-2 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 09시 : 04분
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
저자 및
Ki-Jae Jeong, Caifeng Wang, Jeonghyo Kim, Jaebeom Lee1,*
Department of Cogno-Mechatronics Engineering, Pusan National University, Korea
1Chemistry, Chungnam National University, Korea
Chitosan is one of promising polymers for applications in various fields. However, despite diverse research studies conducted on its biocompatibility, its uses are still limited. The main factor that can affect its physical, chemical and biological properties is the degree of deacetylation (DOD), which represents the proportion of deacetylated units in the polymer. In this article, the in vivo biocompatibility of chitosan-hydroxyapatite composite films composed of chitosan with different DOD values was investigated by traditional biological protocols and novel optical spectroscopic analyses. The DOD of the chitosan was estimated and calculated by Raman spectroscopy, Fourier transform infrared spectroscopy, and proton nuclear magnetic resonance spectroscopy. The chitosan with the higher DOD induced a higher incidence of inflammation in skin cells. The amino group density, biodegradability, and crystallinity of chitosan are three possible factors that need to be considered when determining the biocompatibility of the films for in vivo application, since they led to complicated biological results, resulting in either better or worse inflammation even when using chitosan products with the same DOD. This basic study on the relationship between the DOD and inflammation is valuable for the development of further chitosan-based researches.