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  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

대한화학회 제124회 학술발표회 및 총회 Zr(IV)-Mediated, Versatile Heparin Coating on Solid Surfaces for Antiplatelet Application

등록일
2019년 8월 9일 16시 00분 38초
접수번호
0108
발표코드
POLY.P-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
Polymer Chemistry
저자 및
공동저자
Yeonwoo Jeong, Sung Min Kang*
Department of Chemistry, Chungbuk National University, Korea
Control over platelet adhesion on artificial surfaces has been of great interest because non-specific adhesion of platelet on solid surfaces can cause biomedical devices to malfunction. To avoid these problems, heparin coating has been extensively used. However, previous approaches for heparin coating showed several drawbacks: complicated and time-consuming steps are required. Herein, we developed a facile heparin coating method. Solid surfaces were pretreated with tannic acid/Zr(IV) complexes. Heparin was then deposited on the surface through a spin-coating process and fixed by Zr(IV) mediated crosslinking reaction. Using this approach, TA/Zr(IV)/heparin coatings that are highly resistant to human platelet adhesion were successfully formed on various substrates.

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