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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Injectable, biocompatible conjugated catechol chitosan hydro-gels with ion inducement and ethylenediamine tetra-acetic acid treatment

2019년 8월 14일 15시 08분 31초
POLY.P-6 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 18일 (금요일) 11:00~12:30
Polymer Chemistry
저자 및
Quang Nguyen Ngoc, Daewon Sohn*
Department of Chemistry, Hanyang University, Korea
Chitosan (CS) is a natural polycationic polysaccharide and pH-sensitive polymer with incomplete deacetylation from claiming chitin. It is also a guaranteeing material in terms of pharmaceutical, chemical, and sustenance industry due to its exceptional structure including reactive –OH and –NH2 groups. In this study, catechol-modified chitosan (CCS) for an eminent level for substitution was synthesized and propelled by marine mussel cuticles in place on research those intricate connections between Fe3+ and catechol under acidic conditions. The ratios of catechol, chitosan, and other reagents decide the structure of the hydrogel. The gel formation is then well-maintained by dual cross-linking through electrostatic interactions between CCS and oxidative ions such as Fe3+ and IO4- through covalent catechol-coupling-based coordinate bonds. The hydrogels showed enhanced cohesiveness and shock-absorbing properties at lower pH and ethylenediaminetetraacetic acid (EDTA) treatment due to coordinate bonds inspired by mussel byssal threads. Thus, the gelation time, rheological properties, UV-vis and 1H- Nuclear Magnetic Resonance spectroscopy, and the morphologic aspects were elucidated to describe those cross-linking components and the physical properties of the chitosan backbones and hydrogel frame-works.