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  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Study of D-glucuronic acid-coated Ultrasmall Paramagnetic Ln2O3 (Ln = Tb, Dy, and Ho) Nanoparticles: Water Proton Relaxivities at High Field Magnetic Resonance Imaging

2019년 8월 20일 16시 16분 32초
PHYS.P-152 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 17일 (목요일) 11:00~12:30
Physical Chemistry
저자 및
Shuwen Liu, Gang Ho Lee1,*
Department of chemistry, Kyungpook National University, China
1Department of Chemistry, Kyungpook National University, Korea
Contrast agents have been used since beginning in Magnetic resonance imaging (MRI) to improve the image contrast, through their influence in water proton relaxation times. The paramagnetic lanthanide elements served as valuable contrast medium as they possess excellent magnetic properties useful for MRI while some of these elements have additional optical properties and can serve as fluorescence imaging (FI) agents as well. Herein, we synthesized D-glucuronic acid-coated ultrasmall Ln2O3 (Ln = Tb, Dy, and Ho) nanoparticles by a polyol method to investigate their water proton relaxivities at higher magnetic field (9.4 T). Despite their ultrasmall diameters (~2 nm), all the nanoparticles showed unsaturated but appreciable magnetization of ~4 emu/g at an applied field of 1.8 T at room temperature, and consequently, high transverse water proton relaxivities (r2) with negligible longitudinal water proton relaxivities (r1), thus being eligible for use as T2 contrast agents in MRI. In addition, D-glucuronic acid-coated ultrasmall Tb2O3 nanoparticles exhibited fluorescence in the green region, indicating that they may serve as a dual imaging agent in FI and T2 MRI.