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  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

대한화학회 제124회 학술발표회 및 총회 Zwitterionic Polysulfobetaine Brushes with the Resistance to Nonspecific Protein Adsorption and Platelet Adhesion

2019년 8월 21일 10시 17분 48초
POLY.P-20 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 18일 (금요일) 11:00~12:30
Polymer Chemistry
저자 및
Hyeon Min Shin, Woo Kyung Cho1,*, Yeonwoo Jeong2, Sung Min Kang2
chemistry, Chungnam National University, Korea
1Department of Chemistry, Chungnam National University, Korea
2Department of Chemistry, Chungbuk National University, Korea
Nonspecific protein adsorption on solid surface leads to platelet adhesion onto the surface. As platelet adhesion anditsexcessive accumulation can cause blood coagulation, the inhibition of platelet adhesion/aggregation has been a critical issue for blood-contact medical devices. For example, unnecessary blood coagulation on vascular stents can lead to blockage of blood flow and blood vessel destruction. In addition, medical devices inserted into the body may lose their function. To solve this problem, we aim to develop the functional coating for preventing platelet adhesion/aggregation by grafting zwitterionic sulfobetaine polymer, poly((3-methacryloylamino)propyl-dimethyl(3-sulfopropyl)ammonium hydroxide) (poly(MPDSAH))onto titanium substrate that is a common material for biomedical applications. The polymerization was carried out by activators regenerated by electron transfer for atom transfer radical polymerization (ARGET ATRP). The polymer grafting process was developed as a substrate-independent manner by using polyphenol chemistry. The polymer grafting was characterized by ellipsometry, contact angle goniometry, and X-ray photoelectron spectroscopy(XPS). The resistance to nonspecific protein adsorption on polysulfobetaine-coated substrate was evaluated by using an enzyme-linked immunosorbent assay (ELISA). Compared to bare and polyphenol-coated substrates, poly(MPDSAH)-grafted substrate strongly inhibited nonspecific fibrinogen adsorption, and platelet adhesion/aggregation, showing its antifouling capability and hemocompatibility