abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Development and Biological activity evaluation of saccharin Derivatives from N-hydroxymethyl saccharin

등록일
2019년 8월 23일 14시 32분 24초
접수번호
1583
발표코드
ORGN.P-415 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Seung ryul Lee, Do hun Lee, Eon Jin Lee, Dai Il Jung*
Department of Chemistry, Dong-A University, Korea
Saccharin is an artificial or non-nutritive sweetener. Humans can't break down saccharin, so it leaves the body unchanged. Alkylation methods for preparing N- and O-substituted (carbonyl oxygen) derivatives of 1,2-benzisothiazol-3-one-1,1-dioxide (saccharin) are well established, and these have provided researchers with the straightforward synthesis of novel and potentially bioactive molecules. In addition to N- and O-alkylation, compounds modified in the attached benzene ring are particularly preferred. All types of saccharin derivatives attract very intensive interest in the development of new biologically active and small molecule medicines. We have developed promising derivatives of saccharin via esterification from hydroxymethyl saccharin with acyl chloride(stearoyl chloride, lauroyl chloride, decanoyl chloride, heptanoyl chloride, caproyl chloride, octanoyl chloride, hydrocinnamoyl chloride, etc) and will perform biological activity evaluation of the derivatives.

상단으로