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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Electrogenerated chemiluminescence probe for glutathione based on cyclometalated Ir(III) complex

등록일
2019년 8월 26일 15시 52분 11초
접수번호
1610
발표코드
ORGN.P-421 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Hyun Seung No, Taemin Kim1, Jong-in Hong1,*
Division of chemistry, Seoul National University, Korea
1Division of Chemistry, Seoul National University, Korea
Electrogenerated chemiluminescence probe for glutathione based on cyclometalated Ir(III) complex Hyun Seung No, Jong-In Hong* Department of Chemistry, Seoul National University, Seoul 08826, Korea Glutathione (GSH) is the most abundant intracellular biothiol and plays a critical role as a cellular antioxidant. Abnormal levels of GSH are associated with many diseases. Therefore, various detection methods for GSH have been developed. It is challenging to detect GSH selectively among structurally similar biothiols (Cys, Hcy). Recently, an iridium complex ligated with phenanthroline-dione was developed to detect GSH using redox chemistry. Electrogenerated chemiluminescence (ECL) has received much attention due to advantages such as high sensitivity, no light source, simple analytical process, and applicability to point-of-care testing. Herein, we report ECL chemodosimetric probe for GSH based on cyclometalated Ir(III) complexes having a phenanthroline-dione moiety as an ancillary ligand and a reaction site. Details of spectroscopy, electrochemistry, and ECL studies will be discussed in the presentation.

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