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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Laser desorption/ionization (LDI) mass spectrometry based on nanomaterials for biomedical applications

2019년 8월 26일 17시 07분 49초
ANAL3-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 10시 : 40분
Analytical Chemistry - Recent Trends in Mass Spectrometry
저자 및
Jae-Chul Pyun
Dept. Materials Science and Engineering, Yonsei University, Korea
In conventional MALDI-TOF mass spectrometry, analyte molecules are known to be ionized by mixing with organic matrix molecules. As the organic matrix molecules are ionized, they generate unreproducible mass peaks such that MALDI-TOF mass spectrometry is nearly impossible in the low mass-to-charge (m/z) range (< 1000). In this work, we present laser desorption/ionization (LDI) mass spectrometry based on solid-matrices for the detection of small biomolecules in the low m/z range by using MALDI-TOF mass spectrometry: (1) Top-down synthesized TiO2 nanowires were synthesized as arrays using a modified hydrothermal process directly on the surface of a Ti plate; (2) The nylon nanoweb with TiO2 particles was prepared by the simultaneously electrospinning a nylon nanoweb and electrospraying TiO2 nanoparticles; (3) The parylene-matrix chip was fabricated by the deposition of nano-porous parylene-N thin film on a dried organic matrix array. The biomedical application of LDI mass spectrometry was demonstrated for (1) the detection of chemical and biological warfare agents, (2) the newborn metabolite analysis, (3) the antibiotics-resistant bacteria screening and (4) search for biomarkers for medical diagnosis of sepsis.