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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Hierarchical Chirality Transfer of Peptide Foldamer

등록일
2019년 8월 26일 20시 06분 57초
접수번호
1618
발표코드
ORGN.P-422 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Jungwoo Hong, Jintaek Gong1, Hee-Seung Lee*
Department of Chemistry, Korea Advanced Institute of Science and Technology, Korea
1Natural Science Research Institute, Korea Advanced Institute of Science and Technology, Korea
Peptide foldamers synthesized from achiral amino acids usually forms only racemic helices, not having preference for a particular handness. Helical racemic property of achiral peptide foldamer can be broken by introducing chiral amino acid into peptide sequence, results in a stabilization of single helical configuration. Herein, we prepared series of chiral/achiral heptapeptide foldamers, consisted of four α- and three γ-amino acids. The ratio between two configurations was adjusted via variation of peptide residue and sequence. Co-assembly between chiral and achiral peptide foldamer yields foldecture—self-assembled architecture of foldamers—having the internal molecular packing structures with achiral peptide foldamers adopting single configuration; since only achiral peptide adopting helical structure capable of interacting with chiral peptide can participate in self-assembly process. This study enables hierarchical chirality transfer of peptide foldamer, essential for understanding peptide-peptide interaction under various self-assembly process, ultimately mimicking structural and functional features of natural proteins.

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