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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 The targeted metabolomics profiling of urine in diabetic kidney disease using NMR

2019년 8월 26일 21시 08분 24초
ANAL.P-150 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 18일 (금요일) 11:00~12:30
포스터 분석구두발표
Analytical Chemistry
저자 및
Jin Seong Hyeon, Geum-Sook Hwang*
Korea Basic Science Institute, Korea
Diabetic kidney disease (DKD) is a leading cause of end stage renal disease (ESRD), and the number of patients diagnosed with chronic kidney disease (CKD) and ESRD due to diabetes has been steadily increasing worldwide. To investigate the biomarker for CKD originated from DKD (DM-CKD), we performed the targeted metabolomics profiling using 800 MHz nuclear magnetic resonance spectroscopy (NMR). Prospectively urine samples consecutive patients with DM-CKD stage 1 to 5 (n=208) and controls (n=26) with normal kidney function were analyzed. We found a gradual elevation of glucose, mannose, fumarate, and pyroglutamate according to DM-CKD stages compared with control groups. These four urinary metabolites were significantly correlated with urinary protein-to-creatinine ratio and estimated glomerular filtration rate. After Kaplan-Meier analysis and multivariate Cox analysis, metabolites were associated with ESRD progression. This study demonstrates that the NMR based targeted-metabolomics shed light on understanding of the DM-CKD and enable us to predict the risk of ESRD progression.