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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Antioxidative Activity of Oligosaccharides on UV-induced Photoaging in human skin cells

등록일
2019년 8월 27일 14시 36분 35초
접수번호
1645
발표코드
ANAL.P-153 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (금요일) 11:00~12:30
발표형식
포스터 분석구두발표
발표분야
Analytical Chemistry
저자 및
공동저자
Ara Lee, Dong-Ku Kang*
Department of Chemistry, Incheon National University, Korea
Ultraviolet (UV) is one of the major reasons for the skin aging and its intracellular action mechanisms are well-defined as 1) mitochondrial damage due to UV-induced reactive oxygen species (ROS) and 2) collagen collapse in the subcutaneous layer due to increased expression of matrix metalloproteinase (MMP). Thus, antioxidants are commonly used as an anti-aging agents to inhibit free radicals produced by UV such as ROS. Oligosaccharides are kind of carbohydrates that have various biological activities such as improving intestinal environment and immune stimulation. Recently, antioxidant activity of oligosaccharides has been also identified from few kinds of oligosaccharides. In this study, seaweed-derived oligosaccharides were identified on anti-photoaging that was induced by ultraviolet B (UVB) irradiation in human keratinocytes (HaCaT cells). Reductive activity was validated using conventional ABTS assay with nine individual oligosaccharides and result indicated that neoagarooctaose (NA8) and neoagarodecaose (NA10) have reducing power. In HaCat cell-based antioxidant experiments, NA10 also inhibits ROS formation and ERK 1/2 phosphorylation. Finally, MMP-1 production was also interfered by NA10 treatment in HaCat cells. There experimental results suggested that NA10 has a potential for the skin anti-photoaging.

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